Effects of 5-HT in mianserin-pretreated or cyproheptadine-pretreated rats on the behavioral satiety sequences

Abstract

The intention of the present work was to determine the effects of the 5-HT in rats pretreated with cyproheptadine (5-HT2 receptors antagonist) and mianserin (5-HTc receptors antagonist), administered 10 min before the 5-HT in the hypothalamic paraventricular nucleus (NPH), on the parameters of behavioral satiety sequences. The animals were maintained on a self-selection feeding paradigm and provided with freely available and separate sources of protein, carbohydrate and fat. The results suggest a suppression effect of the ingestion of carbohydrates when administering the 5-HT. This effect was prevented by the mianserin and cyproheptadine pre-treatments. The analysis of the behavioral satiety sequences produced by the pre-treatments of cyproheptadine and mianserin, suggests that the prevention of the effects induced by the 5-HT on food intake was due to delay of the satiation processes with both pre-treatments, affecting different parameters of behavior.